Gilbert Research Group
Explore the Structure, Function, and Movement of Macromolecules
Understanding Potent Lipid Mediators in Cellular Signaling
We reduce biology to the macromolecules/nanomachines that interact with the ions, protons, and molecules to perform the dance of life. At the same time, we are systems-minded biochemists: we use molecular detail as a starting point for understanding how interactions among proteins, lipids, and their environments scale upward to shape pathways and cellular behavior. We ask how amino acid sequence encodes protein folding and conformational motion, and how new functional properties emerge as molecular interactions become increasingly complex. We are especially interested in enzyme mechanisms, interfacial binding, and the ways protein dynamics and function are coupled in living systems.
In our lab, we take a deliberate and iterative approach to science. We value clear hypotheses, thoughtful experimental design, rigorous analysis, and the willingness to revise our models as new evidence emerges.
We also view research as a collaborative form of mentorship. We prioritize student growth, shared ownership of projects, open communication, and transparent recognition of each person’s contributions. Lab members participate in every stage of the scientific process—from developing ideas and troubleshooting experiments to interpreting results, presenting findings, and writing manuscripts—with the goal of preparing them to become confident, independent scientists.
Ultimately, we strive to create a lab culture that balances rigor with curiosity. We take our work seriously while preserving space for questions, creativity, intellectual risk-taking, and genuine enthusiasm for discovery.
A protein’s path to activity runs through folding, dynamics, and molecular interaction.
The Gilbert Lab is a diverse and dynamic group, consisting of a retiree, graduate students, post-baccalaureate researchers, and undergraduate students. We work hard and have fun along the way—come join us!
